Death Toll Ranked – Highest To Lowest

  1. Black Death (Bubonic Plague) – 200M
  2. Smallpox – 56M
  3. Spanish Flu – 40-50M
  4. Plague of Justinian – 30-50M
  5. HIV/AIDS – 25-35M
  6. The Third Plague – 12M
  7. COVID-19 – 6.6M
  8. Antonine Plague – 5M
  9. 17th Century Great Plagues – 3M
  10. Asian Flu – 1.1M
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